Histiocyte Society - Athens 2023 Agenda

2023 ATHENS MEETING AGENDA

Day 1 - Saturday, October 21, 2023

1000 - 1600
1230 - 1330
1500 - 1600
1600 - 1630
1630 - 1800
1630 - 1800
1630 - 1800

Executive Board Meeting*
Lunch (Board)
LCH-IV Study Management Group*
Coffee Break
LCH Steering Committee Meeting*
HLH Steering Committee Meeting*
Rare Histiocytic Disorders Steering Committee Meeting*

Day 2 - Sunday, October 22, 2023

0800 - 1700
0800 - 1000

1000 - 1030

1030 - 1230

1230 - 1330

1330 - 1500

1500 - 1600

1600 - 1630
1630 - 1730
1730 - 1830

1900 - 2100

Meeting Registration and Check-In
LCH Disease Discussion Session

“Around the World with LCH”

Advantages of a common data dictionary to unify CRFs and enable comparison of clinical trial results amongst cooperative groups around the world
Lightening presentations from groups around the world (specifically: COG, NACHO, ECHO, France, Russia, South American, Asia)
Defining the problem: Response Criteria Past and Present (presentations from YI Ilia/mentor Ossama on their lit search and Olive Ecstein/Mark Fluechel to discuss pros/cons Persict vs Recist criteria)
Group Discussion: The path forward: Gaps and Strategy
- We have defined today the different subcommittees necessary to address this – neuroradiology, biostatistics/epi, clinical – radiographic response, biologic response and identified participants that include both sides of ocean as well as senior/YIs.
- Goal: Delphi survey (we have recruited an LCH stats person with DELPHI experience from Europe) with hope to have data to present at HS 2024.

Coffee Break

HLH Disease and MAS Discussion Session

Introduction
Optimized Diagnostic Approaches to HLH: Do They Exist and What Should We Recommend To Clinicians?

Consensus Guidelines Overview

- University and Center HLH Algorithms Overview: Ashish Kumar
- NIH Consensus Effort Guideline: Scott Canna
- Discussion
Models and Indexes to Optimize Diagnostic Testing for the Syndrome of HLH
- Model-Based Review of HLH Diagnostic Criteria: Jan Inge Henter
- OHI and Other Indexes: Adi Zoref-Lorenz
- Discussion

Standard and Alternative HLH/MAS Treatment Roundtable
Brief Pros/Cons of each agent, then Panel Discussion and Questions from Audience

Etoposode - Scott/Kim on behalf of Stephan Ehl, Kai Lehmberg, and HLH Registry
Emapalumab - Mike Jordan
Ruxolitinib - Melissa Hines
IL-18 Targeting Therapies - Ed Behrens
Discussion
METAPHOR Project update– AnnaCarin Horne

Closing with the Cutting Edge (20)

UNC13D Gene Therapy Trial in France (10) - Despina Moshous
CRS/ICANS Update (10) - Carolyn Diorio (Recorded Presentation)

Lunch
Young Investigator's/New Members Lunch w/ Executive Board^
Rare Histiocytoses Disorders Disease Discussion Session

2023 RHD Abstract Highlights
Malignant Histiocytosis Task Force Update
RHD/ECHO JXG Position Paper Update
Patient and Community Perspective on RHD Progress
Overview and discussion of RHD Registries

LCH Education Session
Michael Henry - Combining therapies with MAPK inhibition: Is this the next step?
Ashish Kumar

Coffee Break
HLH Education Session - Scott Canna, Shan Chandrakasan
Rare Education Session - Julien Haroche, Karen Rech

Welcome Reception

Day 3 - Monday, October 23, 2023

0800 - 1700
0800 - 1200
0800 - 0845

0845 - 0900
0900 - 1000
1000 - 1030

1030 - 1230

1230 - 1330

1330 - 1500
1500 - 1530

1530 - 1700
1700 - 1830

1930 - 2230

Meeting Registration and Check-In
Poster Presentation Setup
Education Committee Meeting*
Scientific Committee Meeting*
Opening Ceremonies - Histiocyte Society President, Kim Nichols
Guest Speaker Presentation - "New mechanistic insights into CNS immune privilege" - Jonathan Kipnis
Coffee Break
Judging of Posters 1-5 for Arceci Prize
HLH Symposium: Cutting and Pasting: Gene Therapy Approaches for Primary HLH
"Progress towards transformative gene therapy and genome editing medicines" - Shengdar Tsai
"Agora initiative" - Claire Booth (Virtual Presentation)
"Gene therapy for HLH with a focus on current efforts on UNC13D" - Toni Cathomen
Lunch
Meet the Expert - HLH^ - Ed Behrens
Patient and Family Collaboration Group meeting w/ HS Executive Board
Scientific Session I: Oral Presentations
Coffee Break

Scientific Session II: Presidential Symposium
Poster Presentation Session

Special dinner hosted by Histio Hellas - All are welcome!

Day 4 - Tuesday, October 24, 2023

0800 - 1300
0830 - 0915
0915 - 1000
1000 - 1030

1030 - 1230

1230 - 1330

1330 - 1500
1500 - 1530
1530 - 1600
1600 - 1700
1700 - 1730

1900 - 1159

Meeting Registration and Check-In
Clinical Studies and Registries Update
Jon Pritchard Lecture on the Nikolas Symposium
Coffee Break
Judging of Posters 6-10 for Arceci Prize

LCH Symposium: Hitting the Target: Signaling Pathways Gone Awry in Histiocytosis
"Oncogenic MAPK activation as therapeutic targets across cancers" - Mimi Bandopadhayay
"New signaling pathways in adult histiocytosis" - Gaurav Goyal
"ACCELERATE and Paediatric Strategy Forums" - Andy Pearson
Lunch
Meet the Expert - LCH^ - Patrick Campbell
Meet the Expert - Rare Histiocytoses^ - Eli Diamond
Patient and Family Group Collaboration meeting
Scientific Session III: Oral Presentations
Presentation of Late Breaking Abstracts
Coffee Break
General Assembly Business Meeting*
Executive Board Meeting*
Education Committee Meeting*
Scientific Committee Meeting*

Histiocyte Society Annual Banquet

* Indicates closed session
^ Indicates advance registration required

About the Society

The Histiocyte Society is a nonprofit organization of more than 200 physicians and scientists from around the world committed to improving the lives of patients with histiocytic disorders by conducting clinical and laboratory research into the causes and treatment of this disease.

Contact

secretariat@histiocytesociety.org
Phone: +1 856 589 6606
Fax: +1 856 589 6614
332 N Broadway
Pitman, NJ 08071 USA