Educational Material

Langerhans Cell Histiocytosis (LCH)

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE.J Exp Med. 2014 Mar 17. [Epub ahead of print]

Central nervous system disease in Langerhans cell histiocytosis. Grois N, Fahrner B, Arceci RJ, Henter JI, McClain K, Lassmann H, Nanduri V, Prosch H, Prayer D; Histiocyte Society CNS LCH Study Group.J Pediatr. 2010 Jun;156(6):873-81, 881 

Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including Langerhans cell histiocytosis, juvenile xanthogranuloma and Rosai-Dorfman disease. Simko SJ, Tran HD, Jones J, Bilgi M, Beaupin LK, Coulter D, Garrington T, McCavit TL, Moore C, Rivera-Ortegón F, Shaffer L, Stork L, Turcotte L, Welsh EC, Hicks MJ, McClain KL, Allen CE.Pediatr Blood Cancer. 2014 Mar;61(3):479-87. doi: 10.1002/pbc.24772. Epub 2013 Sep 18.

Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. Gadner H, Grois N, Pötschger U, Minkov M, Aricò M, Braier J, Broadbent V, Donadieu J, Henter JI, McCarter R, Ladisch S; Histiocyte Society.Blood. 2008 Mar 1;111(5):2556-62. Epub 2007 Dec 18. 

Improved Outcome of Treatment-resistant High-risk Langerhans Cell Histiocytosis After Allogeneic Stem Cell Transplantation with Reduced-intensity Conditioning
. M Steiner, S Matthes-Martin, A Attarbaschi, M Minkov, N Grois, E Unger, W Holter, J Vormoor, A Wawer, M Ouachee, W Woessmann and H Gadner

Incidence and pattern of radiological central nervous system Langerhans cell histiocytosis in children: a population based study. Laurencikas E, Gavhed D, Stålemark H, van't Hooft I, Prayer D, Grois N, Henter JI.Pediatr Blood Cancer. 2011 Feb;56(2):250-7.  

Langerhans cell histiocytosis: Current concepts and treatments. Abla O, Egeler RM, Weitzman S.Cancer Treat Rev. 2010 Jun;36(4):354-9. doi: 10.1016/j.ctrv.2010.02.012. Epub 2010 Feb 25. Review

Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Haupt R, Minkov M, Astigarraga I, Schäfer E, Nanduri V, Jubran R, Egeler RM, Janka G, Micic D, Rodriguez-Galindo C, Van Gool S, Visser J, Weitzman S, Donadieu J; Euro Histio Network.Pediatr Blood Cancer. 2013 Feb;60(2):175-84.

Management of Adult Patients with Langerhans Cell Histiocytosis: Recommendations from an Expert Panel on Behalf of Euro-Histio-Net. Michael Girschikofsky, Maurizio Arico, Diego Castillo, Anthony Chu, Claus Doberauer, Joachim Fichter, Julien Haroche, Gregory A Kaltsas, Polyzois Makras, Angelo V Marzano, Mathilde de Menthon, Oliver Micke, Emanuela Passoni, Heinrich M Seegenschmiedt, Abdellatif Tazi and Kenneth L McClain

Neuropsychological Problems in Langerhans Cell Histiocytosis. Vasanta Nanduri; Edda Unger; Nicole Grois

Pathologic Diagnosis of the Histiocytic Disorders of Childhood. Ronald Jaffe

Recurrent BRAF mutations in Langerhans cell histiocytosis. Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ.Blood. 2010 Sep 16;116(11):1919-23. doi: 10.1182/blood-2010-04-279083. Epub 2010 Jun 2.

Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, Astigarraga I, Braier J, Donadieu J, Henter JI, Janka-Schaub G, McClain KL, Weitzman S, Windebank K, Ladisch S; Histiocyte Society.Blood. 2013 Jun 20;121(25):5006-14. doi: 10.1182/blood-2012-09-455774. Epub 2013 Apr 15.

Updates on histiocytic disorders.Vaiselbuh SR, Bryceson YT, Allen CE, Whitlock JA, Abla O.Pediatr Blood Cancer. 2014 Mar 9. doi: 10.1002/pbc.25017.

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